In conjunction with the promotion of their live album La Revolución: Live, on June 2010 the duó announced to work on the continuation of their collaborative albums from Los Vaqueros. The same month it were confirmed collaborations with Tego Calderón, Franco "El Gorila", Cosculluela and De La Ghetto on the track "La Reunión De Los Vaqueros" song that later was included on their live album, as well the release date in November 2010. Later, they announced the track "Tu Olor" as the album's first single but is changed for "Zun Zun Rompiendo Caderas". Early November 2010, they announced that the album's first single will feature American rappers 50 Cent and T-Pain, as well the album's title. The album cover and tracklist was revealed on December 18, 2010.
In United States, Los Vaqueros: El Regreso debuted at #8 with sales of 31,000 on the Billboard 200. It became Wisin & Yandel's second top ten album and highest album debut on the top ten after La Revolución debuted at #7 in 2009. It also debuted at #1 on the Billboard Top Latin Albums, and became their fifth number one album on the chart. On the Top Rap Albums the album debuted at #2, becoming on their highest debut on the chart.
John Bush from Allmusic said that "It's an LP that's meant to evoke 2006's crew-laden Los Vaqueros, which firmly established reggaeton's first family with appearances by Don Omar and Franco "El Gorilla", as well as a host of newcomers. This one is similarly studded with nearly a dozen stars and up-and-coming talents -- Unlike many of their contemporaries, who clearly can't contain a parade of collaborators in a seamless whole, Wisin & Yandel easily shuttle between pop, urban, and reggaeton with few speed bumps." Frances Tirado from Primerahora said that "This album is great for the fans of reggaeton, because the lyrics speak mainly of the club environment and conquer of girls, the love and heartbreak -- Music producers participating, injected the electronic dance sounds of classic reggaeton to make a salad urban music."